Medicinal chemistry has spent more than a century perfecting the flat aromatic ring, and that mastery now confronts a stubborn limitation. Most small-molecule drugs still resemble thin sheets of carbon and nitrogen, planar structures that bind efficiently but explore...
Molecular flatness has quietly become one of the most consequential liabilities in modern medicinal chemistry, and the reason is deceptively simple: shape governs biological recognition. A drug molecule does not merely need the right atoms in the right order; it must...
Medicinal chemistry has long operated on a costly assumption: that discovering a genuinely new drug requires building a genuinely new molecule, atom by atom, from the ground up. That assumption is now being dismantled by a discipline called skeletal editing, which...
